HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethoxybenzoyl chloride → N-(3-tert-Butyl-1,2-thiazol-5-yl)-2,6-dimethoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethoxybenzoyl chloride | HCID 74810 | — |
| Reactant | 1,2-Thiazol-5-amine | HCID 19939721 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(3-tert-Butyl-1,2-thiazol-5-yl)-2,6-dimethoxybenzamide | HCID 13239369 | 30% |
Reaction Steps
A solution of the 5-amino-isothiazole and 1.1 g of 2,6-dimethoxybenzoyl chloride in 50 ml of toluene was heated at reflux for two hours, during which time a precipitate formed. The precipitate was collected by filtration and dried to give 340 mg of N-[3-(1,1-dimethylethyl)-5-isothiazolyl]-2,6-dimethoxybenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636243 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-2840d31ede8a405bbc251f0e469b8182 |
| Source note | uspto-grants-1987_01 |