Water → HCID 12795542, compound

Participants

Reaction Steps

A suspension of 5-chloropyrimidin-2-one (408 mg). and 2-bromo-4'-trifluoromethyl-acetophenone (824 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for 45 mins. Water (100 ml) was added and the precipitate was collected. This solid was crystallised from acetone to give the title pyrimidinone (571 mg,); m.p. 243°-245°; λmaxEtOH 235.5 nm (ε 20040), 282 nm (ε 1880), 333.5 nm (ε 1860), λinf 287.5 nm (ε 1790).

Provenance & Evidence