HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 12795550, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Chloro-2(1H)-pyrimidinone | HCID 108578 | — |
| Reactant | N-[4-(Bromoacetyl)phenyl]benzamide | HCID 12537708 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 12795550 | HCID 12795550 | 49.6% |
Reaction Steps
A suspension of 5-chloropyrimidin-2-one (338 mg) and 4'-benzamido-2-bromoacetophenone (766 mg) in triethylamine (1 ml) and dimethylformamide (10 ml) was stirred at ambient temperature, giving a solution, quickly followed by formation of a precipitate. After 45 mins, water (100 ml) was added to the suspension. The collected solid was crystallised from glacial acetic acid to give the title pyrimidinone (439 mg,); m.p. 290°-303°; λmaxEtOH 226 nm (ε 16230), 302.5 nm (ε 20370).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636509 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-19343eca45de4de2b7471de3fe432f1b |
| Source note | uspto-grants-1987_01 |