HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 12795551, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(Bromoacetyl)benzonitrile | HCID 98654 | — |
| Reactant | 5-Chloro-2(1H)-pyrimidinone | HCID 108578 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 12795551 | HCID 12795551 | 45.3% |
Reaction Steps
A suspension of 5-chloropyrimidin-2-one (412 mg) and 2-bromo-4'-cyanoacetophenone (677 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for one hour. Water (100 ml) was added and the collected solid was crystallised from ethyl acetate to give the title pyrimidinone (375 mg,); m.p. 236°-240°; λmaxEtOH 248 nm (ε 26140), 289 nm (ε 2130), λinf 254 (ε 22800).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636509 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-d59fe64291994f588fb1128ec034ca5f |
| Source note | uspto-grants-1987_01 |