2,6-Dimethyl-4-hydroxy-furano[2,3-c]pyridine → 6-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

HRID 980190Notes

Reaction equation

HRID 980190 reaction equation
C[CH:2]1[O:12][C:5]2=[CH:6][N:7]([CH3:11])[CH:8]=[C:9]([OH:10])[C:4]2=[CH:3]1.Cl.OC1CN(C)CC2OC=CC1=2.C(C1OC2=CN(C)C=C(O)C2=C1)C>>[OH:10][CH:9]1[CH2:8][N:7]([CH3:11])[CH2:6][C:5]2[O:12][CH:2]=[CH:3][C:4]1=2

Participants

4

Reactant 3

HCID 704313132,6-Dimethyl-4-hydroxy-furano[2,3-c]pyridineHCID 704317682-Ethyl-4-hydroxy-6-methyl-furano[2,3-c]pyridineHCID 704319024-Hydroxy-6-methyl-4,5,6,7-tetrahydro-furano[2,3-c]pyridine hydrochloride2×

Product 1

HCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Procedure

The compounds 2,6-dimethyl-4-hydroxy-furano[2,3-c]pyridine (melting point of the hydrochloride: 189°-190° C.) and 2-ethyl-4-hydroxy-6-methyl-furano[2,3-c]pyridine (melting point of the hydrochloride: 176°-178° C.) were also obtained in this way.

Workup

  1. custom189°-190° C.
  2. custom176°-178° C.) were also obtained in this way

Sources & evidence

ORD record
ord-b688ce51166548eb9d2fbf9196cde209
Source dataset
uspto-grants-1987_01
Patent number
US04636510

Reaction notes

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