反应详情

Two grams (0.005 mol) of 4-hydroxy-4-(p-bromophenyl)-6-methyl-4,5,6,7-tetrahydro-furano[2,3-c]pyridine were heated to 50° C. for four hours in 40 ml of a boron trifluoride/methanol mixture (20% BF3), and then the mixture was poured onto ice and neutralized with ammonia. The mixture was extracted with ether, and the ether was distilled off in vacuo. The residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)].

1. extractionThe mixture was extracted with ether
2. distillationthe ether was distilled off in vacuo
3. customThe residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)]