Ammonia → HCID 70432000, compound

Participants

Reaction Steps

Twenty grams (0.08 mol) of 2-furfuryl-2-methyl-amino-1-p-methyl-phenyl-ethanol were dissolved in 100 ml of ethylene chloride and heated to boiling point for three hours with 100 ml of trifluoroacetic acid. The reaction mixture was poured onto ice and neutralized with concentrated ammonia. The organic constituents were extracted with ether. Aftery drying, the ether was distilled off in vacuo. The residue was purified over silica gel [cyclohexane/ethyl acetate (1:1)]. After the solvent was distilled off in vacuo, the residue was dissolved in acetate. After addition of ethereal hydrochloric acid, the hydrochloride of the title compound crystallized out.

Provenance & Evidence