反应详情

A solution of 4-(2,6-difluoro-3-nitrophenyl)pyridine (10.9 g) in ethanol (500 ml) was hydrogenated (50 p.s.i.) for 1 hour over 15 g of Raney Nickel. The reaction mixture was then filtered through diatomaceus earth and the filtrate was evaporated in vacuo to give the product as a white solid of m.p. 190°-192° C. (6.6 g, 68% yield). NMR (DMSO d6, 250 MHz): 8.7 (m, 2H), 7.5 (m, 2H), 6.95 (m, 2H).

1. customfor 1 hour
2. filtrationThe reaction mixture was then filtered through diatomaceus earth
3. customthe filtrate was evaporated in vacuo