Nitric Acid → 6-(2,6-Difluoro-3-nitrophenyl)-quinoline

Participants

Reaction Steps

The title compound was prepared by the method of Example 1B. A 5.00 g sample (70% yield) was made from 6-(2,6-difluorophenyl)-quinoline (6.02 g, 25 mmoles) and 50 ml of concentrated H2SO4 and 1.5 ml of concentrated HNO3. The product was isolated as an off white solid of m.p. 152°-153° C. NMR (DMSO-d6, 250 MHz): 9.05 (d of d, 1H), 8.50 (d, J=5 Hz, 1H), 8.40 (sextet, 1H), 8.24 (s, 1H), 8.20 (d, J=5.0 Hz, 1H), 7.87 (d, J=5.0 Hz, 1H), 7.60 (m, 2H).

Provenance & Evidence