HCID 13578788, compound → HCID 178456096, compound

Participants

Reaction Steps

Using the procedure of Step C of Example 3, 8 g of the product of Step B, 80 ml of tetrahydrofuran and 1.9 g of 4-dimethylaminopyridine were reacted to obtain 6.8 g of 1,1-dimethylethyl N-[(S) 1-[4-hydroxy-3-[(2-thiazolyl-amino)-carbonyl]-8-(trifluoromethyl]-quinolin-2-yl]-propyl]-carbamate melting at 260°-262° C. and having a specific rotation of [α]D =+66.5°±2.5° (c=0.7% in CH3COOH).

Provenance & Evidence