Dichloromethane → HCID 178456063, compound

Participants

Reaction Steps

A mixture of 6.5 g of the product of Example 7, 130 ml of methylene chloride and 65 ml of trifluoroacetic acid was stirred for 2 hours at ambient temperature and then the methylene chloride and trifluoroacetic acid were eliminated under reduced pressure. The residue was taken up in iced water and the pH was adjusted to 7 with a solution of sodium bicarbonate. The mixture was filtered and the product was washed and dried under reduced pressure at 100° C. The product obtained was dissolved at reflux in 120 ml of acetonitrile and the solution was filtered. The filtrate was concentrated to 100 ml and the crystals obtained were frozen, separated, washed and dried under reduced pressure at 100° C. to obtain 3.25 g of 2-[(S) 1-aminopropyl]-4-hydroxy-N-(2-thiazolyl)-8-trifluoromethyl-3-quinoline-carboxamide melting at 206° C. and having a specific rotation of [α]D =+177°±2.5° (c=0.8% in CH3COOH).

Provenance & Evidence