2-Dimethylaminopyridine → HCID 178454163, compound

Participants

Reaction Steps

Using the procedure of Step C of Example 7, a solution of 28 g of the product of Step B in 280 ml of tetrahydrofuran and 5.25 g of dimethylaminopyridine were reacted to obtain 16.9 g of 1,1-dimethylethyl N-[(S) 1-[4-hydroxy-3-[(2-thiazolylamino)-carbonyl]-8-(trifluoromethyl)-quinolin-2-yl]-2-(1H-indol-3-yl)-ethyl]-carbamate melting at 270° C. and having a specific rotation of [α]D =+33°±2° (c=0.5% in CH3COOH).

Provenance & Evidence