2-(2-Bromo-1,1,2,3,3,3-hexafluoropropanoxy)-1,3-dichlorobenzene → 7-Chloro-2,2,3-trifluoro-3-trifluoromethyl-2,3-dihydrobenzofuran

Participants

Reaction Steps

In a manner similar to Step C of Example 2, the reaction of 12.8 g (0.033 mole) 2-(2-bromo-1,1,2,3,3,3-hexafluoropropanoxy)-1,3-dichlorobenzene, 10.4 g (0.16 mole) activated copper powder, and 2.3 g (0.0033 mole) bis(triphenylphosphine)palladium II chloride in 225 ml of dimethyl sulfoxide produced 4.3 g of 7-chloro-2,2,3-trifluro-3-trifluoromethyl-2,3-dihydrobenzofuran as an oil. The nmr spectrum was consistent with the proposed structure.

Provenance & Evidence