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4-(2,3-Epoxypropoxy)salicylic acid methyl ester → 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-(3-hydroxy-4-methoxycarbonylphenoxy)propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2,3-Epoxypropoxy)salicylic acid methyl ester | HCID 12611335 | — |
| 反応物 | 5-(2-Benzylaminopropoxy)salicylamide | HCID 13754334 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-(3-hydroxy-4-methoxycarbonylphenoxy)propan-2-ol | HCID 53695657 | — |
反応手順
After 40 hours' boiling and working up analogously to Example 4a), 22.4 g of 4-(2,3-epoxypropoxy)salicylic acid methyl ester and 30 g of 5-(2-benzylaminopropoxy)salicylamide in 200 ml of isopropanol yield crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-(3-hydroxy-4-methoxycarbonylphenoxy)propan-2-ol as a light-coloured foam which is further processed as a crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04636511 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-edfe8f19374a4d2b9e898ef79a35945f |
| 出典メモ | uspto-grants-1987_01 |