Methanesulfonyl chloride → HCID 20222398, compound

Participants

Reaction Steps

A stirred solution of 3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-methylethyl]-1H-indole-5-methanamine (3.29 g) in dry pyridine (50 ml) cooled in an ice bath was treated with methanesulphonyl chloride (1.64 ml). After 18 h at room temperature the solvent was removed under reduced pressure and the resulting viscous orange oil poured into a mixture of ice and concentrated hydrochloric acid (200 ml) to give a pink solid which was purified by chromatography on kieselgel 60 (200 g) eluted with ethyl acetate/cyclohexanane (1:1) to give the title compound as a yellow foam (0.28 g). This material was used without further purification.

Provenance & Evidence