Water → HCID 12822512, compound

Participants

Reaction Steps

Methyl iodide (0.15 ml) was added to a stirred solution of N-[[3-[(dimethylamino)methyl]-1H-indol-5-yl]methyl]methanesulphonamide (0.5 g) in dimethyl sulphoxide (20 ml) followed by potassium cyanide (0.3 g) and the resulting solution stirred for 2 h, before pouring it into water (80 ml) and extracting with ethyl acetate (2×30 ml). The combined organic extracts were washed with water (30 ml), hydrochloric acid (2N, 30 ml) dried (Na2SO4) and evaporated to dryness to give a fawn foam which was purified on a silica column (kieselgel 60, 10 g) eluted with ethyl acetate to give the title compound as a white solid (0.08 g) m.p. 106°-9° after crystallisation from ethyl acetate.

Provenance & Evidence