Methylamine → HCID 12822473, compound

Participants

Reaction Steps

A solution of N-[[3-(cyanomethyl)-1H-indol-5-yl]methyl]methanesulphonamide (0.04 g) in absolute ethanol (10 ml) containing methylamine in ethanol, (33%, 0.5 ml) was hydrogenated at room temperature and pressure over palladium on charcoal (10%, 50% aqueous paste, 0.05 g). After 60 h TLC Silica, ethyl acetate/2-propanol/water/0.88 ammonia (25:15:2) showed one major basic spot Rf 0.4, identical to authentic product (see Example 2)

Provenance & Evidence