HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → 8-Chloro-2,3,4,5-tetrahydro-2-[3-(2-pyridinyl)-propyl]-1H-pyrido[4,3-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 8-Chloro-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole | HCID 904970 | — |
| Reactant | 3-Pyridinylpropyl bromide hydrobromide | HCID 67937748 | — |
| Product | 8-Chloro-2,3,4,5-tetrahydro-2-[3-(2-pyridinyl)-propyl]-1H-pyrido[4,3-b]indole | HCID 13772457 | — |
Reaction Steps
The title compound was prepared following the procedure of Example 1 with the exception that 3-pyridinylpropyl bromide hydrobromide was used instead of 4-pyridinylbutyl bromide hydrobromide and 8-chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole was used instead of 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole. The product as converted to the dihydrochloride salt; mp. 240°-242° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636563 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-f4fa169be3394a23840d269872810f8e |
| Source note | uspto-grants-1987_01 |