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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 980317Generated: October 30, 2026

Tetrafluoro-m-phenylenediamine dihydrochloride → 8-Chloro-2,3,4,5-tetrahydro-2-[3-(2-pyridinyl)-propyl]-1H-pyrido[4,3-b]indole

https://huagongshe.com/reaction/980317

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrafluoro-m-phenylenediamine dihydrochlorideHCID 149026—
Reactant8-Chloro-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indoleHCID 904970—
Reactant3-Pyridinylpropyl bromide hydrobromideHCID 67937748—
Product8-Chloro-2,3,4,5-tetrahydro-2-[3-(2-pyridinyl)-propyl]-1H-pyrido[4,3-b]indoleHCID 13772457—

Reaction Steps

The title compound was prepared following the procedure of Example 1 with the exception that 3-pyridinylpropyl bromide hydrobromide was used instead of 4-pyridinylbutyl bromide hydrobromide and 8-chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole was used instead of 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole. The product as converted to the dihydrochloride salt; mp. 240°-242° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04636563
Source datasetuspto-grants-1987_01
ORD IDord-f4fa169be3394a23840d269872810f8e
Source noteuspto-grants-1987_01