4-Vinylpyridine → Carvotroline

HRID 980318Notes

Reaction equation

HRID 980318 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)=[CH2:2].[C:9]1(N)[C:14]([F:15])=[C:13](F)[C:12](F)=[C:11]([NH2:18])[C:10]=1F.Cl.Cl>>[F:15][C:14]1[CH:9]=[CH:10][C:11]2[NH:18][C:3]3[CH2:8][CH2:7][N:6]([CH2:2][CH2:1][C:3]4[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=4)[CH2:5][C:4]=3[C:12]=2[CH:13]=1

Participants

3

Reactant 2

HCID 75024-VinylpyridineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

Product 1

HCID 72038Carvotroline

Procedure

The title compound was prepared following the procedure of Example 2 with the exception 4-vinylpyridine was used instead of 2-vinylpyridine. The product was converted to the dihydrochloride salt; mp. 233°-235° C.

Sources & evidence

ORD record
ord-1aed1f85481042ccb490ad5a7e0adcbe
Source dataset
uspto-grants-1987_01
Patent number
US04636563

Reaction notes

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