Sodium thiocyanate → HCID 13107038, compound

HRID 980346Notes

Reaction equation

Cl.[NH2:2][CH:3]([CH2:21][CH3:22])[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.[S-:23][C:24]#[N:25].[Na+]>>[C:17]([C:8]1[CH:7]=[C:6]([C:4]2[NH:25][C:24](=[S:23])[NH:2][C:3]=2[CH2:21][CH3:22])[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]=1[OH:16])([CH3:20])([CH3:19])[CH3:18]

Participants

Reactant 2

HCID 516871Sodium thiocyanate

HCID 20222370HCID 20222370, compound

Product 1

HCID 13107038HCID 13107038, compoundYield 45.2%

Procedure

By following the same procedure as in Example 8 using 13.1 g of 2-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-butanone hydrochloride, 6.5 g of sodium thiocyanate, 3.4 ml of concentrated, and 100 ml of acetic acid and recrystallizing the reaction product from isopropanol, 6 g of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-ethyl-2-thioxo-4-imidazoline was obtained.

Workup

concentrationof concentrated
custom100 ml of acetic acid and recrystallizing the reaction product from isopropanol

Sources & evidence

ORD record: ord-7122f1811f0f475fb400b5158af75c0a
Source dataset: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04636516

Reaction notes

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