反应详情

A mixture of 1.65 g of 6-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,3-dihydroimidazo[2,1-b]thiazole, 1.8 g of morpholine, 1.7 g of an aqueous 35% formaldehyde solution, 1.5 ml of acetic acid, and 10 ml of dioxane was refluxed for 6 hours. The reaction mixture was concentrated udner reduced pressure and to the residue was added 20 ml of an aqueous 10% potassium carbonate to precipitate crystals, which were recovered by filtration and recrystallized from methanol to provide 0.85 g of 6-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-morpholinomethyl-2,3-dihydroimidazo[2,1-b]thiazole.

1. temperaturewas refluxed for 6 hours
2. concentrationThe reaction mixture was concentrated udner reduced pressure
3. additionto the residue was added 20 ml of an aqueous 10% potassium carbonate
4. customto precipitate crystals, which
5. filtrationwere recovered by filtration
6. customrecrystallized from methanol