反应详情

温度

0 °C

In 10 ml of methanol was dissolved 1.3 g of 6-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-thiocyanato-2,3-dihydroimidazo[2,1-b]thiazole and after cooling the solution to 0° C., 0.65 g of methyl iodide was added dropwise to the solution with stirring and further a solution of 0.2 g of potassium hydroxide dissolved in a mixture of 2 ml of water and 2 ml of methanol was added dropwise to the solution. After 30 minutes, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography using chloroform as the eluent and further recrystallized from ethanol to provide 0.18 g of 6-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-methylthio-2,3-dihydroimidazo[2,1-b]thiazole.

1. additionwas added dropwise to the solution
2. concentrationthe reaction mixture was concentrated
3. customthe residue was purified by silica gel column chromatography
4. customfurther recrystallized from ethanol