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(S)-Benzyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate → (2S)-N,N-dimethylpyrrolidine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-Benzyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate | HCID 13564352 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (2S)-N,N-dimethylpyrrolidine-2-carboxamide | HCID 7408249 | 99% |
反応手順
In 86 ml of ethanol was dissolved 4.3 g of compound (88) and after adding thereto 210 mg of 10% palladium-carbon, the mixture was stirred vigorously for 90 minutes in a hydrogen stream. After filtering off the catalyst, ethanol was distilled off under reduced pressure to provide 2.19 g of crude (S)-N,N-dimethyl-2-pyrrolidinecarboxamide (89).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04636567 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-e0b51b11410e47e893e7d60908173161 |
| 出典メモ | uspto-grants-1987_01 |