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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 980395Generated: October 25, 2026

(S)-1-benzyloxycarbonyl-N-[3-(2-oxo-pyrrolidinyl)propyl]-2-pyrrolidine carboxamide → (S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamide

https://huagongshe.com/reaction/980395

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-1-benzyloxycarbonyl-N-[3-(2-oxo-pyrrolidinyl)propyl]-2-pyrrolidine carboxamideHCID 18601121—
CatalystHCID 178418390HCID 178418390—
SolventMethanolHCID 887—
Product(S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamideHCID 5395867471.9%

Reaction Steps

In 150 ml of methanol was dissolved 4.32 g of compound (99) and the compound was hydrogenated using 432 mg of 10% palladium-carbon as a catalyst. Then, the catalyst was filtered off from the reaction mixture and the filtrate was concentrated to provide 1.99 g of (S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamide (100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04636567
Source datasetuspto-grants-1987_01
ORD IDord-7552ec8dc7cf49c6b31a05bbd87b1257
Source noteuspto-grants-1987_01