HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → HCID 44576190, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | HCID 54438809 | HCID 54438809 | — |
| Reactant | HCID 131715016 | HCID 131715016 | — |
| Product | HCID 44576190 | HCID 44576190 | — |
Reaction Steps
Ac-Phe-Gly-Ala-LeuCH2Cl was prepared by condensation of N-acetyl-L-phenylalanylglycyl-L-alanine with leucine chloromethyl ketone hydrochloride using a mixed anhydride procedure employing isobutyl chloroformate, Powers et al., Biochem. Biophys. Acta. 480:246-261 (1977), describes an analogous procedure. Crude product was recrystallized from ethyl acetate to provide a white crystalline solid, m.p. 152.4°-153.8° (reported m.p. 167°-168°).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636492 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-854f8b7948fd47e2b2e45d40bf49be0f |
| Source note | uspto-grants-1987_01 |