HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 71777655, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | Alanine methyl ester hydrochloride | HCID 2733257 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11821341 | HCID 11821341 | — |
| Product | HCID 71777655 | HCID 71777655 | 137.8% |
Reaction Steps
Boc-Gly-Ala-OCH3 was prepared by coupling Boc-Gly-OH (35.0 g, 200 mmol) to H-Ala-OCH3.HCl (27.9 g, 200 mmol) using a mixed anhydride procedure. The resulting product (43.5 g, 167 mmol) was deblocked with anhydrous HCl in dioxane. After deblocking, crystallization from dioxane:ether yielded 27.1 g of H-Gly-Ala-OCH3.HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04636492 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-b528ff6954804d788ce17ba7e5cdc1d1 |
| Source note | uspto-grants-1987_01 |