Anisole → HCID 131714620, compound

Participants

Reaction Steps

Z-Phe-Gly-Ser-LeuCH2Cl was prepared by the following procedure. First, Z-Phe-Gly-Ser(OCH2C6H5)LeuCH2Cl (0.98 g, 14.4 mmol) was deblocked by treatment with 15 mL of anhydrous HF and 1 mL of anisole (Procedure K) to yield 0.69 g of H-Phe-Gly-Ser-LeuCH2Cl.HF. This intermediate (0.59 g, 12.4 mmol) was then coupled with carbobenzoxychloride substantially according to the procedure of Procedure K to yield 0.4 g of Z-Phe-Gly-Ser-LeuCH2Cl (m.p. 146°-146.5°) after crystallization from ethyl acetate/hexane.

Provenance & Evidence