Calcium Carbonate → HCID 20446511, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 0.05 mol (8.35 g) of 2-methyl-4-amino-5-nitroaniline and 0.035 mol (3.5 g) of calcium carbonate in 100 ml of water are first heated on a boiling waterbath, while stirring. 0.07 mol (14.35 g) of β-bromoethylaniline hydrobromide dissolved in 20 ml of water is added a little at a time, while stirring. After the reaction mixture had been heated on a boiling waterbath for 2 hours, it is filtered hot. After the filtrate has been cooled at 0° C. for 24 hours, the expected product, which has crystallised in the form of the hydrobromide, is filtered off with suction. The crude product is washed with acetone and then recrystallised from boiling water. After filtering off with suction, washing with acetone and drying in vacuo, 2-methyl-4-amino-5-nitro-N-β-aminoethylaniline hydrobromide monohydrate is obtained.

Provenance & Evidence