Boron tribromide → HCID 178444417, compound

Participants

Reaction Steps

A solution of the 2-(trans-4-pentylcyclohexyl)-1-(2-fluoro-4-methoxyphenyl)-ethane (9.0 g, 0.0294 mol) obtained according to section (c) in absolute dichloromethane (100 ml) was added dropwise to a solution of boron tribromide (11.0 g, 0.0441 mol) and absolute dichloromethane (100 ml) under virtually anhydrous conditions at 0° C. The mixture thus formed was stirred for 1 hour and then poured onto ice water. The organic phase was separated off, and the aqueous phase was extracted again with dichloromethane (2×50 ml). The combined organic phases were washed with water and dried over magnesium sulfate. The crude product obtained after evaporation was recrystallized from hexane at 0° C. 8.5 g (98% yield) of pure target product were obtained.

Provenance & Evidence