HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 13911212, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 13911211 | HCID 13911211 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 13911212 | HCID 13911212 | 94.3% |
Reaction Steps
A solution containing compound 1 (15.0 g, 55.4 mmol), K2CO3 (20.0 g, 0.145 mol) and CH3I (30 mL, 0.48 mol) in 250 mL acetone was refluxed for 6 hours. The solvent was evaporated and the residue partitioned between CH2Cl2 and H2O. The organic layer was dried over Na2SO4, filtered and evaporated to leave a yellow-white powder. Recrystallization from CH3OH/pet ether at -20° C. gave 14.9 g of white crystals (94%). The material was characterized by NMR, TLC, mass spectroscopy, IR and elemental analysis, m.p. 131°-132.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04637988 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-29119fca4f0041939369756d4cb01c1c |
| Source note | uspto-grants-1987_01 |