HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 980452Generated: October 30, 2026
cis-3-[2,6-Dimethylpiperidinyl]propylamine → N-[3-[2,6-dimethyl-1-piperidinyl]propyl]-hexahydro-5-oxo-1H-pyrrolizine-3-carboxamide
https://huagongshe.com/reaction/980452
Participants
| Role | Name | HCID | Charge |
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| Reactant | cis-3-[2,6-Dimethylpiperidinyl]propylamine | HCID 7176132 | — |
| Reactant | hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid ethyl ester | HCID 13756031 | — |
| Product | N-[3-[2,6-dimethyl-1-piperidinyl]propyl]-hexahydro-5-oxo-1H-pyrrolizine-3-carboxamide | HCID 20221664 | — |
Reaction Steps
A solution of hexahydro-5-oxo-1H-pyrrolizine-3 carboxylic acid ethyl ester (5.0 g, 0.0254 mol) in cis-3-[2,6-dimethylpiperidinyl]propylamine (34 g, 0.2 mol) is stirred at room temperature 24 hours and heated at 80° C. for 24 hours. The solution is concentrated at reduced pressure and distilled to yield N-[3-[2,6-dimethyl-1-piperidinyl]propyl]hexahydro-5 oxo1H-pyrrolizine-3-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04638006 |
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| Source dataset | uspto-grants-1987_01 |
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| ORD ID | ord-64d8189fd5414a63934102d63b3f7cb5 |
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| Source note | uspto-grants-1987_01 |
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