HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyrrolidine, hydrochloride (1:1) | HCID 212848 | — |
| Reactant | 1-(4-cyclohexylphenyl)propan-1-one | HCID 1226260 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 1-Propanone, 1-(4-cyclohexylphenyl)-2-methyl-3-(1-pyrrolidinyl)- | HCID 3024470 | — |
Reaction Steps
A solution of 5.10 g of 4'-cyclohexylpropiophenone in 15 ml of ethyl acetate, 2.50 g of pyrrolidine hydrochloride, 1.30 g of paraformaldehyde and 0.5 ml of 22% hydrogen chloride-ethyl acetate were treated in the same manner as that described for Example 3 to give 3.65 g of hydrochloride of the desired compound, which were recrystallized from a mixture of ethanol and ether as colorless needles, mp 186°-187°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04638009 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-caca97d53b1e47b98fccfce1dcdece30 |
| Source note | uspto-grants-1987_01 |