HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxide → 3-(Pyrazin-2-yl)acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxide | HCID 961 | — |
| Reactant | Chloral | HCID 6407 | — |
| Reactant | 2-Methylpyrazine | HCID 7976 | — |
| Reactant | 2-(Pyrazin-2-yl)propanoic acid | HCID 17864951 | — |
| Product | 3-(Pyrazin-2-yl)acrylic acid | HCID 305608 | — |
Reaction Steps
Scheme M depicts a specific synthesis of a pyrazinyl propionic acid. Methylpyrazine anion is condensed with trichloroacetaldehyde followed by treatment with base (hydroxide), then acidification to produce 3-(-Pyrazinyl) Acrylic Acid 75. This acid is then catalytically hydrogenated over palladium on charcoal to yield 3-(2-Pyrazinyl)propionic Acid 76.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04638005 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-c13ea9ac38ac4cf591514329645f7d16 |
| Source note | uspto-grants-1987_01 |