Methyl iodide → HCID 20221612, compound

HRID 980474Notes

Reaction equation

HRID 980474 reaction equation
[Na+].[N:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([O-:11])(=[O:10])=O.[CH3:12]I>>[CH3:12][N:5]1[CH:6]=[CH:7][NH:2][C:3](=[S:8](=[O:10])=[O:11])[CH2:4]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 88656262HCID 88656262, compound

Product 1

HCID 20221612HCID 20221612, compound

Procedure

4.0 g of Pyrazine-2-sulfonic acid sodium salt (1900) was added to a solution of 20 ml methyl iodide/40 ml methanol and the mixture refluxed for 7 days. The solvent was evaporated and the residue chromatographed (Biogel P-2/water) giving 3.5 g of product (2000) which was recrystallized from ethanol/water, m.p. 270°-2° (dec). UV H2O max: 282 (3.86).

Workup

  1. temperaturethe mixture refluxed for 7 days
  2. customThe solvent was evaporated
  3. customthe residue chromatographed (Biogel P-2/water)

Sources & evidence

ORD record
ord-a9445a35c5984fbfae0df3e1a9988611
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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