Methyl iodide → HCID 86741226, compound

Participants

Reaction Steps

5.0 g of 2-(2-sulfonylethyl)pyrazine sodium salt (2500) was added to a solution of 10 ml methyl iodide/50 ml methanol and the mixture refluxed for 4 days. It was then concentrated and purified by gel permeation chromatography (Biogel P-2/water). Freeze-drying gave 4.5 g of product (2600). It was recrystallized from ethanol/water, m.p. 255-60 (dec.). UV H2O max: 281 (3.87). 13C NMR: 162.99, S (C3); 150.63, D (C5); 138.51, D, 136.24, D (C2, C6); 49.66, Q (NCH3); 49.56, T (CH2SO3); 31.44, T (ArCH2). 1H NMR: 9.33, D,T (H6); 8.99, S (H2); 8.82, D (H5); 4.48, S (NCH3); 3.58-3.43, M (--CH2 --).

Provenance & Evidence