1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 54065281, compound

Participants

Reaction Steps

7.0 g of 2-(1-bromo-3,4-diacetoxybutyl)pyrazine (4102 and 4103) was dissolved in 100 ml of toluene, 3.3 g of 1,8-diazabicyclo [5.4.0]undec-7-ene added under an argon atmosphere and the solution heated overnight at 65°-70°. It was then cooled, the toluene solution decanted and concentrated in vacuo. The residue was chromatographed on silica gel (hexane/ethyl acetate) to yield 3.5 g of 2-(3,4-diacetoxy-1-butenyl)pyrazine (4104) as a pale yellow oil. UV EtOH max: 240 (4.14), 292 (3.85), 298 (3.86).

Provenance & Evidence