Bromine → 2-Bromo-1-(3,4-dihydro-2H-1-benzothiopyran-6-yl)-1-propanone

Participants

Reaction Conditions

Reaction Steps

To a solution of 32 gr. of 6-propionyl-thiochromane in 400 ml of anhydrous ether, 8 ml of bromine are dropwise added, temperature being maintained at ±5° C. After addition, the mixture is still stirred for 2 to 3 hours at room temperature, than an aqueous saturated NaHCO3 solution is slowly added. The aqueous phase is twice extracted with 100 ml ether, combined organic phases are dried on MgSO4, filtered, and solvent is evaporated in vacuo. The residue so obtained is treated with 100 ml of petroleum ether; 38 gr. of α-bromo-6-propionyl-thiochromane are obtained.

Provenance & Evidence