HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → trans-1-(4-Methoxy-2-hydroxymethylanilino)-2-ethoxycarbonylaminoindane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Barium Carbonate | HCID 10563 | — |
| Reactant | trans-1-Chloro-2-ethoxycarbonylaminoindane | HCID 7070371 | — |
| Reactant | (2-Amino-5-methoxyphenyl)methanol | HCID 13756678 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | trans-1-(4-Methoxy-2-hydroxymethylanilino)-2-ethoxycarbonylaminoindane | HCID 54338086 | 44% |
Reaction Steps
A solution of 2-amino-5-methoxybenzyl alcohol (5 g; 32.7 m.mol) and trans-1-chloro-2-ethoxycarbonylaminoindane (7.83 g; 32.7 m.mol) in dimethylformamide (80 ml) was treated with barium carbonate (3.37 g; 17 m.mol) in a manner similar to that in Description 3 to give the title compound (5.1 g; 44%), m.p. 142°-144° (from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04638066 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-0fec37ce11ae4e1f907027a22e157250 |
| Source note | uspto-grants-1987_01 |