反应详情

A mixture of 2.43 g (9.00 mmol) of N-(5-amino-1,2,4-triazol-3-yl)-2-nitrobenzenesulfonamide and 1.85 ml (1.80 g, 18.0 mmol) of 2,4 pentanedione in 25 ml of glacial acetic acid was heated at reflux for 19 hours. After cooling to room temperature, the solid which separated was collected by filtration, washed with acetic acid and dried in vacuo to yield 2.58 g (82 percent) of the desired product as an off-white crystalline solid, mp 255°-256° C. IR and 1H NMR spectra were in agreement with the assigned structure.

1. temperaturewas heated
2. temperatureat reflux for 19 hours
3. customthe solid which separated
4. filtrationwas collected by filtration
5. washwashed with acetic acid
6. customdried in vacuo