Sodium Acetate → HCID 13730721, compound

HRID 980534Notes

Reaction equation

HRID 980534 reaction equation
[C:1]([C:3]([NH:8][C:9](=[O:15])/[CH:10]=[CH:11]\[C:12]([OH:14])=O)([CH3:7])[CH:4]([CH3:6])[CH3:5])#[N:2].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH:4]([C:3]([CH3:7])([N:8]1[C:9](=[O:15])[CH:10]=[CH:11][C:12]1=[O:14])[C:1]#[N:2])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 86741235HCID 86741235, compound

Product 1

HCID 13730721HCID 13730721, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of N-(1-cyano-1,2-dimethylpropyl)maleamic acid (595 g, 2.83 mol) in acetic anhydride (3.96 liters) containing sodium acetate (13.72 g, 0.167 mol) is heated under reflux for one hour, cooled and the solvent removed in vacuo. The product is distilled* at 120°-130° C./0.1 mm to give 337 g (63%) of product.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for one hour
  3. temperaturecooled
  4. customthe solvent removed in vacuo
  5. customis distilled* at 120°-130° C.

Sources & evidence

ORD record
ord-cbe48fb439c64ab58445ae9d65d16598
Source dataset
uspto-grants-1987_01
Patent number
US04638068

Reaction notes

Loading…