7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → 1-Ethyl--6-fluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid
Reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10](Cl)[N:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2].Cl.Cl.[CH2:21]([N:23]1[CH2:27][CH2:26][C:25]2([CH2:31][CH2:30][NH:29][CH2:28]2)[CH2:24]1)[CH3:22]>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:14])=[C:10]([N:29]3[CH2:30][CH2:31][C:25]4([CH2:26][CH2:27][N:23]([CH2:21][CH3:22])[CH2:24]4)[CH2:28]3)[N:11]=2)[C:6](=[O:15])[C:5]([C:16]([OH:18])=[O:17])=[CH:4]1)[CH3:2]Participants
3
Procedure
The title compound was prepared according to example 24 by reacting 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid with 2-ethyl-2,7diazaspiro[4.4]nonane dihydrochloride; mp 215°-217° C. (dec).
Sources & evidence
- ORD record
- ord-1e0883e4d832464f8c35bcadde262b8e
- Source dataset
- uspto-grants-1987_01
- Patent number
- US04638067
Reaction notes
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