HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 6,7,8-Trifluoro-1,4-dihydro-1-(1-methylethyl)-4-oxo--quinolinecarboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Ethyl 3-oxo-(2,3,4,5-tetrafluorophenyl)propanoate | HCID 600916 | — |
| Reactant | 6,7,8-Trifluoro-1,4-dihydro-1-isopropyl-4-oxoquinoline-3-carboxylic acid | HCID 13477692 | — |
| Product | 6,7,8-Trifluoro-1,4-dihydro-1-(1-methylethyl)-4-oxo--quinolinecarboxylic Acid | HCID 54227490 | — |
Reaction Steps
Using the procedure of Example VV with isopropyl amine, 3.0 g (11.33 mmol) of 2,3,4,5-tetrafluoro-β-oxo-benzeneproprionic acid, ethyl ester was converted to 1.21 g of 6,7,8-trifluoro-1,4-dihydro-1-(1-methylethyl)-4oxo-3-quinolinecarboxylic acid, mp 256°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04638067 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-718f4780e205405fa64940004934e9f3 |
| Source note | uspto-grants-1987_01 |