Sodium Hydroxide → HCID 13648332, compound

HRID 980750Notes

Reaction equation

HRID 980750 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:9]2[C:13]([C:14]([Cl:17])([Cl:16])[Cl:15])=[N:12][C:11]([C:18]([O:20]C)=[O:19])=[N:10]2)[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+]>CO.O>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([N:9]2[C:13]([C:14]([Cl:16])([Cl:17])[Cl:15])=[N:12][C:11]([C:18]([OH:20])=[O:19])=[N:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 13648331HCID 13648331, compound

Product 1

HCID 13648332HCID 13648332, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

210 g (0.54 mole) of 1-(3-trifluoromethylphenyl)-3-methoxycarbonyl-5-trichloromethyl-1,2,4-triazole in 540 ml of methanol were initially taken, and 0.57 mole (22.8 g) of NaOH in 100 ml of water was added. After being stirred at room temperature for 5 hours, the mixture was poured into 4,000 ml of water, the undissolved substance was filtered off and the clear filtrate was adjusted to pH 1 with hydrochloric acid. Colorless crystals were precipitated and were filtered off with suction and washed with water. The substance which remained undissolved in water--the sodium salt of the carboxylic acid--was dissolved in a mixture of 2,000 ml of methanol and 1,000 ml of water, the pH of the solution was adjusted to 1 with hydrochloric acid, and the colorless crystalline precipitate was filtered off with suction and washed with water.

Workup

  1. filtrationthe undissolved substance was filtered off
  2. customColorless crystals were precipitated
  3. filtrationwere filtered off with suction
  4. washwashed with water
  5. dissolutionthe sodium salt of the carboxylic acid--was dissolved in a mixture of 2,000 ml of methanol and 1,000 ml of water
  6. filtrationthe colorless crystalline precipitate was filtered off with suction
  7. washwashed with water

Sources & evidence

ORD record
ord-a003626318114f578564c8e46bd1c866
Source dataset
uspto-grants-1987_01
Patent number
US04639266

Reaction notes

Loading…