HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium ethylxanthate → 2-Amino-4-methoxy-6-ethoxythiocarbonylthiomethyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium ethylxanthate | HCID 2735045 | — |
| Reactant | 4-(Chloromethyl)-6-methoxypyrimidin-2-amine | HCID 13884815 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-4-methoxy-6-ethoxythiocarbonylthiomethyl-pyrimidine | HCID 54223721 | — |
Reaction Steps
16.0 g of potassium ethylxanthogenate and 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the reaction solution has cooled, it is diluted with about 1 liter of water, and the product which precipitates is separated and dried. The yield is 22.5 g (87% of theory) of 2-amino-4-methoxy-6-ethoxythiocarbonylthiomethyl-pyrimidine, m.p. 91°-93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639264 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-7c9db8c7bd554c099a4079ead2f9d381 |
| Source note | uspto-grants-1987_01 |