HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-Benzyl-3-cyanoazetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-benzylazetidin-3-ol | HCID 3801345 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Benzyl-3-cyanoazetidine | HCID 19814762 | — |
Reaction Steps
1.7 g of 2A, and 1.2 g of sodium cyanide were stirred together in 1 ml of water and 20 ml of dimethylformamide at 60° C. for 16 hours. The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using isopropanol in dichloromethane as eluent to give 1-benzyl-3-cyanoazetidine (2B), yield 0.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639334 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-7ae90c1b65b04bb7a0bfde3d3cde9f52 |
| Source note | uspto-grants-1987_01 |