Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (4-Methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanol | HCID 13247995 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131714665 | HCID 131714665 | — |
Reaction Steps
Methane sulphonyl chloride (13.4 ml) is added dropwise to a stirred solution of 5-methoxy-1-hydroxymethyl benzocyclobutene (26 g) and triethylamine (26.5 ml) in methylene chloride (670 ml) cooled to 0° C. under nitrogen. The reaction mixture is allowed to warm to RT, stirred for 2 hours at RT, washed with water and saturated salt, dried over Na2SO4, and filtered. The filtrate is concentrated in vacuo yielding the desired product as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04639442 |
|---|
| Source dataset | uspto-grants-1987_01 |
|---|
| ORD ID | ord-44b4876a464e4f8780c58120eccea4af |
|---|
| Source note | uspto-grants-1987_01 |
|---|
