Dichloromethane → HCID 131715046, compound

Participants

Reaction Steps

Aqueous potassium hydroxide (45%) is added to a stirred solution of the hydrochloride salt of the piperidinylmethylbenzocyclobutene obtained in the preceding step (6.5 g) in methylene chloride (30 ml) under nitrogen. The solution is stirred at RT for 30 minutes, and tetrabutylammonium chloride (0.9 g) and 1,3-dibromopropane (26 ml) are added to the stirred reaction mixture. The reaction mixture is stirred for an additional 2.5 hours, diluted with methylene chloride, washed with water, and extracted with 5% aqueous HCl. The acidic extract is washed with ether and basified affording a cloudy solution, which is extracted with methylene chloride. The organic extract is washed with sat'd NaCl solution, dried, filtered and evaporated in vacuo affording the desired product as an oil.

Provenance & Evidence