Salicyloyl chloride → HCID 13228910, compound

HRID 980817Notes

Reaction equation

HRID 980817 reaction equation
[C:1](Cl)(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:14][CH:13]=1>C1C=CC=CC=1>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:14][CH:13]=1)=[O:9]

Participants

4

Reactant 2

HCID 74041Salicyloyl chlorideHCID 161928Ici 109,081

Product 1

HCID 13228910HCID 13228910, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

1.2 Grams (7.7 m-mol) of salicyloyl chloride and 1.0 g (4.9 m-mol) of 6-(p-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in 10 ml of benzene were stirred for 6 hours at 50° C. After cooling, the resultant crystals were washed with benzene and recrystallized from methanol-water whereby 750 mg of the title compound was obtained. M.P. 218°-220° C.

Workup

  1. temperatureAfter cooling
  2. washthe resultant crystals were washed with benzene
  3. customrecrystallized from methanol-water whereby 750 mg of the title compound
  4. customwas obtained

Sources & evidence

ORD record
ord-5eb1a41605e54aceab1804f3469ba064
Source dataset
uspto-grants-1987_01
Patent number
US04639451

Reaction notes

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