2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20220996, compound

Participants

Reaction Steps

A mixture of 4.8 g (0.02 mol) of 2-chloro-4-amino-6,7-dimethoxyquinazoline, 4.6 g (0.022 mol) of (3-oxo-5,5-dimethyl-1-cyclohexen-1-yl)-piperazine and 80 ml of isoamyl alcohol is boiled under reflux for 3 hours, with stirring. During the reaction time, the monohydrochloride precipitates. The mixture is left to stand overnight and the crystals are filtered off with suction. After washing with 40 ml of isoamyl alcohol and twice with in each case 40 ml of absolute acetone and 40 ml of absolute ether and drying, 7.1 g of the hydrochloride of 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-(3-oxo-5,5-dimethyl-1-cyclohexen-1-yl)-piperazine (78% yield) of melting point 267°-268° C. (decomposition) are obtained.

Provenance & Evidence