Sodium borohydride → HCID 86741239, compound

HRID 980839Notes

Reaction equation

HRID 980839 reaction equation
[BH4-].[Na+].[O:3]=[C:4]1[C:14]2[CH:13]=[CH:12][C:11](=[O:15])[NH:10][C:9]=2[CH:8]=[CH:7][C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]1=2>O.CO>[OH:3][C:4]1[C:14]2[C:9]([NH:10][C:11](=[O:15])[CH2:12][CH:13]=2)=[CH:8][CH:7]=[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=12

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 13772002HCID 13772002, compound

Product 1

HCID 86741239HCID 86741239, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 0.30 gram (8 millimoles) of sodium borohydride in 5 milliliters of water is added to a solution of 0.70 gram (3 millimoles) of 5-oxo-benzo[4,5]cyclohepta[1,2-b]pyrid-2(1H)one (prepared as described in Example I) in 50 milliliters of methanol and the resulting mixture heated for about twenty minutes at reflux temperature to obtain the desired 5-hydroxy-benzo[4,5]cyclohepta[1,2-b]pyrid-2(1H)one in the reaction mixture. The product is recovered by evaporating the solvent, and washing and drying the residue.

Workup

  1. temperaturethe resulting mixture heated for about twenty minutes
  2. temperatureat reflux temperature

Sources & evidence

ORD record
ord-974000fc6a1e4bdd8578fdf20066f37c
Source dataset
uspto-grants-1987_01
Patent number
US04639457

Reaction notes

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